01Psilocybin
A classic psychedelic. Mushroom strength and individual responses vary.
02LSD
Also a classic psychedelic, generally with a longer experience.
03MDMA
Works differently. Its physical risks and medication interactions need separate consideration.
Evidence reviewed: September 27, 2026.
Psilocybin, LSD and MDMA are often discussed together. They are not interchangeable. Their effects, duration and medication interactions differ.
People’s experiences overlap and vary within these broad groups. See Holze et al. (2022): controlled comparison of psilocybin and LSD and the BMJ clinical review for background. Our medication review explains why evidence about one combination cannot be applied to another.
Before comparing experiences, compare the practical questions
- What am I hoping for, and what other options could help?
- What is known about this substance with my health history and medications?
- Who could support me during the experience and afterward?
- What would make postponing the better choice?
Read more about psilocybin, LSD and MDMA, then begin with the Preparation Guidebook.